Removing the tools menu unless you are in edit means you can no longer select edit before rezzing, in other words those houses you buy as consolodated linksets, you know... the ones without rezzers, can no longer be moved easily as you set them up.

Then we have the ridiculous double click to run behaviour, that breaks alot of content (Vote at http://jira.secondlife.com/browse/VWR-6232 -- 70 votes so far in 10 hours)

Then the removal of friends from the map, meaning there is no quick way to map people (you now need top open friends, then open profile, then press find on map if it's been allowed by that friend)

Hmmm, the shipped colour scheme is terrible, luckily there is already a skin for the old colours... http://www.rpgstats.com/SL/Dazzle-Retro.zip