As has been said, a permadeath game would need serious retooling from current game mechanics. I never played Dofus. Never even heard of it, so I can only draw on games I know. WoW, EQ etc. I'll use WoW as an example

Permadeath? Forget high level end game stuff. I don't care HOW l33t you are, you are not going to get to 70. You're not going to get to 30!! You -might- make it to 20 without a single death ... maybe ... if you crawl through greenies, barely getting a smidge of exp in your grind.

Loot? Loot can't matter. It would HAVE to be a skill based game, not driven by loot. Why? People will be permadying left and right. Few will be able to gather the best loot.

Forget crafting too. Spend hours looking for whatever ingrediants, learning to make the whatever, only to die before you can make the whatever?

A permadeath server would be very different from what MMO players are used to.